10 Best Cold Sore & Fever Blister Treatments 2025

Looking for the best cold sore and fever blister treatment? Look no further! We've reviewed and scored many products in the OTC medication and treatment subcategory, ranging from a 7.4 score up to a 9.7 score. And the top-rated product that we highly recommend is Abreva. Abreva's 10 Percent Docosanol Cold Sore Treatment is clinically proven to shorten healing time and is the only FDA-approved OTC medication to heal your fever blister in just 2.5 days. Say goodbye to the discomfort and embarrassment of cold sores with Abreva. Trust us, you won't be disappointed!